GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2730245 | 1 | rs6965685 | chr7:158726462 | WDR60 | chr7:158649269-158738882:+ | -0.15 | -3.92 | 0.000104 | Height |
| THCA | cis | rs2243480 | 1 | rs6966322 | chr7:65646754 | CCT6P1 | chr7:65216092-65228661:+ | -0.42 | -6.7 | 5.9E-11 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs6966322 | chr7:65646754 | CRCP | chr7:65579805-65619551:+ | 0.3 | 4.63 | 4.66E-6 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs6966322 | chr7:65646754 | LOC493754 | chr7:65993446-66057363:- | -0.29 | -3.36 | 0.000833 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs6966322 | chr7:65646754 | RABGEF1 | chr7:66093890-66276446:+ | -0.57 | -7.14 | 3.42E-12 | Diabetic kidney disease |
| THCA | cis | rs14978 | 1 | rs6969722 | chr7:12278437 | VWDE | chr7:12370509-12443852:- | -0.24 | -4.15 | 3.9E-5 | Response to amphetamines |
| THCA | cis | rs1801085 | 1 | rs6969780 | chr7:27159136 | HOXA9 | chr7:27202058-27205149:- | -0.38 | -4.38 | 1.48E-5 | Hypospadias |
| THCA | cis | rs875971 | 1 | rs6970030 | chr7:65968679 | ASL | chr7:65540776-65558321:+ | -0.16 | -4.21 | 3.03E-5 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs6970030 | chr7:65968679 | GUSB | chr7:65425675-65447246:- | 0.27 | 5.32 | 1.57E-7 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs6970030 | chr7:65968679 | RABGEF1 | chr7:66093890-66276446:+ | 0.66 | 14.13 | 3.92E-38 | Aortic root size |
| THCA | cis | rs2243480 | 1 | rs6970243 | chr7:65388490 | CCT6P1 | chr7:65216092-65228661:+ | 0.39 | 6.18 | 1.36E-9 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs6970243 | chr7:65388490 | CRCP | chr7:65579805-65619551:+ | -0.26 | -3.99 | 7.58E-5 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs6970243 | chr7:65388490 | RABGEF1 | chr7:66093890-66276446:+ | 0.54 | 6.71 | 5.64E-11 | Diabetic kidney disease |
| THCA | cis | rs2285947 | 1 | rs6970597 | chr7:21583519 | DNAH11 | chr7:21582833-21941455:+ | -0.26 | -5.6 | 3.72E-8 | Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma) |
| THCA | cis | rs2285947 | 1 | rs6970985 | chr7:21583597 | DNAH11 | chr7:21582833-21941455:+ | -0.26 | -5.65 | 2.75E-8 | Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma) |